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Gavin D
14 April 2020 13:00:12
Wales have reported 238 new cases and 19 new deaths
doctormog
14 April 2020 13:01:30
Actually reading a further article on the study the researchers explicitly state “the questions of SARS-CoV-2 infection and replication in primary T cells and whether the infection induces apoptosis in T cells still need further research, potentially evoking new ideas about pathogenic mechanisms and therapeutic interventions.”

This is the paper in question and I actually believe it is the one that was meant to be cited in the news article:

https://www.nature.com/articles/s41423-020-0424-9 

Gandalf The White
14 April 2020 13:01:32


 


I didn't read it Peter. 


Another bad habit I hold at present - relying on unnecessarily dramatic media headlines.  


 


Originally Posted by: Joe Bloggs 


Having seen your thread in the FA I would recommend strongly taking very little that's posted here at face value and certainly not being swayed by a poster's comments unless you know they have expertise in the field or are offering calm commentary.


Location: South Cambridgeshire
130 metres ASL
52.0N 0.1E


Gavin D
14 April 2020 13:02:58
Scotland have reported 291 new cases and 40 new deaths
fairweather
14 April 2020 13:03:59

On a more optimistic note people on forums (us!) are usually very interested and very well informed. But like people who complain about a product on line, people don't often write in and say they didn't have a problem. The worst case scenarios are often the most discussed. The risk of infection is relatively low for people following the lock down. What is the sample size on here? How many of us have had it so far? There, that's cheered you up a bit! Of course outside it is a lot higher. The aim would be in the medium term to try and get the risk as low outside as it is in lock down to keep buying time. That might take a lot of lock downs and a lot more sensible people than we have but I think it can be done.


If 50,000 die in a year it is terrible. But that is approx 0.1% (if my maths is better than some!). You wouldn't bet on a horse at a 1000/1 and expect to win.


 


S.Essex, 42m ASL
pfw
  • pfw
  • Advanced Member
14 April 2020 13:07:30

The ONS data today finally gives an indication of a crucial number - how many extra people is the virus actually killing at the moment? Eyeballing at the graphs it looks to be around 40% up. Not good.


The UK still appears to be tracking Italy very closely in terms of cases/million. If that's the case then 20,000 is a lower bound on death toll and we'd expect to hit it in around 14 days' time.


Endgame still seems unclear. We don't know enough about the virus yet as far as I can tell.


I remember reading "The Coming Plague: Newly Emerging Diseases in a World out of Balance" by Laurie Garrett about 10 years ago now. Good book - I recall finding it pretty convincing, but then of course I forgot about it and went back to life. It's now seeming rather prophetic.


--
Paul.
Gavin D
14 April 2020 13:08:40
Northern Ireland have reported 85 new cases and 10 new deaths
Gandalf The White
14 April 2020 13:08:48

Actually reading a further article on the study the researchers explicitly state “the questions of SARS-CoV-2 infection and replication in primary T cells and whether the infection induces apoptosis in T cells still need further research, potentially evoking new ideas about pathogenic mechanisms and therapeutic interventions.”

This is the paper in question and I actually believe it is the one that was meant to be cited in the news article:

https://www.nature.com/articles/s41423-020-0424-9

Originally Posted by: doctormog 


Again, thanks Michael.


Quoting from that article


"These results suggest that SARS-CoV-2 may enter MT-2 cells at 6 h post infection, but does not replicate, and then the viral RNA degrade."


 


So, fundamentally different to the HIV mechanism.


Location: South Cambridgeshire
130 metres ASL
52.0N 0.1E


Gavin D
14 April 2020 13:11:03
Breaking: NHS England have reported 744 new deaths up from 667 yesterday 
NickR
14 April 2020 13:11:18


I was disgusted to see in one of todays papers that the Social Market Foundatiion called for the axing of the pensioners triple lock on pensions - The argument - so called is that it will save £5 billion a year.


Typical of some so called pressure group to come up with so called laudible ideas - which in essence will leave a group worse off thinking that it will save some money for so called other uses.


Given the figures these days on government spening £5 billion is small fry.


Why can't they just leave things alone and call on more imaginative ways of dealing with things such as working out how to get the economy in top gear in the shortest time possible.


This will generate a lot more than just £5 billion a year - So leave pensioner groups alone.


Originally Posted by: Hungry Tiger 


The triple lock is a disgrace. The pensioner group it benefits are on average far better off and have benefited from decades of economic boom, leaving them in a far better position than other sections of society.


This was from 3 years ago, and it remains correct.


https://www.theguardian.com/money/2016/nov/06/triple-lock-pension-should-scrapped-mps-generational-inequalities


Why are you defending it, Gavin?


Nick
Durham
[email protected]
xioni2
14 April 2020 13:13:16


I’m not even sure we can compare death rates by country because some were not counting those who had underlying problems but tested positive.  I think Germany was one, which explained their low numbers. 


Originally Posted by: Caz 


I have never read this from a German source, its more likely to be hearsay in the UK. 

Heavy Weather 2013
14 April 2020 13:14:22

813 UK deaths today. That's higher than I was expecting.


Mark
Beckton, E London
Less than 500m from the end of London City Airport runway.
Saint Snow
14 April 2020 13:15:05


 


We certainly should. There's no shortage of brain power in the UK! The problems (IMHO and I know others strongly disagree) are to do with the centralised structure of the NHS. I also would question the quality of their IT departments in general. I'm not making a blanket generalisation as I'm sure they have some outstanding people. 


Originally Posted by: Brian Gaze 


 


I'd say the biggest problem is a convoluted and bloated management structure, which has been exacerbated by decentralisation into small Trusts - which, through idiotic political dogma, are often in competition with each other.


Too often, it seems, the greatest control is given to beancounters and career 'management executives' who work to their own agendas, instead of to clinical staff who know what resources are needed and how they should be allocated. 



Martin
Home: St Helens (26m asl) Work: Manchester (75m asl)
A TWO addict since 14/12/01
"How can wealth persuade poverty to use its political freedom to keep wealth in power? Here lies the whole art of Conservative politics."
Aneurin Bevan
Gavin D
14 April 2020 13:19:48
The patients were aged between 34 and 102 years old.

58 of the 744 patients were aged between 38 and 96 years old and had no known underlying health conditions
warrenb
14 April 2020 13:20:59


 


I have never read this from a German source, its more likely to be hearsay in the UK. 


Originally Posted by: xioni2 


Apparently it is to do with the initial source of infection. 90% of Germany's initial infected were 30-40 years olds returning from skiing, they in turn infected the same age group, and therefore had a higher chance of recovery, then they locked down.


Over here by all accounts the initial source was older people returning from Cruises and overseas holidays, thus infecting the same age group and being much older, a higher death rate, then we locked down.


 


So it looks like it due to the initial spreaders being a different demographic between the countries and much higher testing also bringing their death to infect ratio down as well.


 


Gavin D
14 April 2020 13:22:01

Regional breakdown of the deaths. The North West seems to be a bit of a hot spot at the moment.



  • London 206

  • North West 143

  • Midlands 109

  • East of England 95

  • North East & Yorkshire 93

  • South East 73

  • South West 25

Hungry Tiger
14 April 2020 13:22:51


 


The triple lock is a disgrace. The pensioner group it benefits are on average far better off and have benefited from decades of economic boom, leaving them in a far better position than other sections of society.


This was from 3 years ago, and it remains correct.


https://www.theguardian.com/money/2016/nov/06/triple-lock-pension-should-scrapped-mps-generational-inequalities


Why are you defending it, Gavin?


Originally Posted by: NickR 


You only have to look at how the UK state pension compares with much of the rest of Western Europe.


 


The last section of that article is the best -


 


"But pension experts warned that pensioner incomes will start falling within the next decade, even with the triple lock. David Sinclair of the International Longevity Centre, said “While it is right to debate cuts to pensioner benefits, we must take care not to throw the baby out with the bathwater. This debate cannot be about young versus old.”


Tom McPhail, of advisers Hargreaves Lansdown, said: “Politicians are chronically compromised when making any policy decisions [that] might be detrimental to older citizens. You only have to look at the turnout in general elections to understand why: 78% of the over-65s voted, compared to just 43% of the eligible under-25s.


“The triple lock has served an important function in bringing pensioner incomes back into line with the rest of the population. It is also important to recognise that pensioner incomes will change again in the future, we are about to hit ‘peak DB’ after which successive pensioners will be increasingly reliant on the state pension and on defined contribution arrangements. Any measure to curb either of these in the next few years could rapidly push more pensioners back into poverty.”


Gavin S. FRmetS.
TWO Moderator.
Contact the TWO team - [email protected]
South Cambridgeshire. 93 metres or 302.25 feet ASL.


Gandalf The White
14 April 2020 13:25:41


 


The triple lock is a disgrace. The pensioner group it benefits are on average far better off and have benefited from decades of economic boom, leaving them in a far better position than other sections of society.


This was from 3 years ago, and it remains correct.


https://www.theguardian.com/money/2016/nov/06/triple-lock-pension-should-scrapped-mps-generational-inequalities


Why are you defending it, Gavin?


Originally Posted by: NickR 


This is most certainly not a subject for discussion here but you've only put one side of the story. A decade of absurdly low interest rates has given those with mortgages a huge benefit whilst reducing the income from savings of the generation you say benefited from 'decades of economic boom'.  For those reliant on a money-purchase pension scheme the collapse in annuity rates, linked to low interest rates and increasing life expectancy, has had a significantly detrimental effect on their retirement income.


I would have expected a less one-sided view, given your evident intelligence.


Location: South Cambridgeshire
130 metres ASL
52.0N 0.1E


Retron
14 April 2020 13:27:11


You only have to look at how the UK state pension compares with much of the rest of Western Europe


Originally Posted by: Hungry Tiger 


Well, 1 in 5 pensioners are millionaires and no, they don't all live in big houses in the SE (or smaller houses in London!)


Those who are millionaires could easily manage without an extra few hundred pounds a year.


 


Leysdown, north Kent
Gavin D
14 April 2020 13:28:23

Breakdown of the 744 deaths by date in England



  • 122 on April 13th

  • 319 on April 12th

  • 132 on April 11th

  • 164 between April 1st and April 10th

  • 7 in March with one on March 23rd

Roger Parsons
14 April 2020 13:28:47


I have to say I think that's highly improbable, Brian.  Unless you have information that I don't the virus doesn't attack the body like that.  Indeed the opposite is the case, if I understand it: the immune system goes into overdrive to fight the virus and that causes the complications (lung damage).


Originally Posted by: Gandalf The White 


I agree, Gandalf, but what the "natural history" of this pathogen will be once it reaches an equilibrium remains to be seen. We do not yet know the long term reliability of any immunity resulting from having CO-19. Nor do we know where the virus will be able to "hide out" in the human population or perhaps some reservoir host. We will be ill advised to let up on the present strategies for  reducing transmission before we have something effective in place to protect us, a vaccine or other medical treatment. That will take time and the prospect of a sequence of CO-19 peaks if we relax our present efforts is deeply worrying. Roger


RogerP
West Lindsey district of Lincolnshire
Everything taken together, here in Lincolnshire are more good things than man could have had the conscience to ask.
William Cobbett, in his Rural Rides - c.1830
warrenb
14 April 2020 13:28:56

A pension discussion for another thread I think, do you ?


Heavy Weather 2013
14 April 2020 13:33:50
Does anyone understand why reported UK deaths is less that the four nations added togeagher?
Mark
Beckton, E London
Less than 500m from the end of London City Airport runway.
Hungry Tiger
14 April 2020 13:34:02


A pension discussion for another thread I think, do you ?


Originally Posted by: warrenb 


You're quite right - My apologies - I only brought it up as I saw it in a business section of one of the papers referring to the overall costs of the Coronavirus Pandemic.


 


Gavin S. FRmetS.
TWO Moderator.
Contact the TWO team - [email protected]
South Cambridgeshire. 93 metres or 302.25 feet ASL.


doctormog
14 April 2020 13:34:22


 


I have never read this from a German source, its more likely to be hearsay in the UK. 


Originally Posted by: xioni2 


Yes the Robert Koch Institure president confirmed last month that any deaths where the patient had Covid-19 were being recorded as “Covid-19” irrespective of whether it was the direct cause of death or not. So the lower rate (as discussed by Warren) is likely to be for other reasons.


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