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Gavin D
23 March 2020 14:22:57

First patients enrolled in clinical trial of possible Covid-19 treatments


 




Quote


The first UK patients have been enrolled in a clinical trial for possible Covid-19 treatments. Researchers from the University of Oxford have launched a new clinical trial to test the effects of potential drug treatments for patients admitted to hospital with the virus. There are currently no specific treatments for the coronavirus and it is possible some existing drugs used for other conditions may have some benefits. Scientists say the randomised evaluation of Covid-19 therapy (recovery) trial will provide doctors and the health service with information they need to determine which treatments should be used.


The treatments initially included in the study have been recommended by an expert panel that advises the chief medical officer in England. They are Lopinavir-Ritonavir, which is normally used to treat HIV, and the steroid dexamethasone, which is used in a wide range of conditions to reduce inflammation. The side effects and safety of both drugs are already well known.


Other potential treatments will also be assessed by the trial in the future. Peter Horby, professor of emerging infectious diseases and global health in the Nuffield department of medicine, University of Oxford, and chief investigator for the trial, said: “There is an urgent need for reliable evidence on the best care for patients with Covid-19. “Providing possible new treatments through a well-designed clinical trial is the best way to get that evidence.” 





 


https://www.thewestmorlandgazette.co.uk/news/national/18327465.first-patients-enrolled-clinical-trial-possible-covid-19-treatments/


Gooner
23 March 2020 14:23:53


 


I heard a junior minister on LBC earlier this afternoon. The impression I got is there will be no changes announced today. 


Originally Posted by: Brian Gaze 


PM will give it a few days before doing anything else - I think we are probably a week away from any type of lockdown


Remember anything after T120 is really Just For Fun



Marcus
Banbury
North Oxfordshire
378 feet A S L


warrenb
23 March 2020 14:24:26


 


I heard a junior minister on LBC earlier this afternoon. The impression I got is there will be no changes announced today. 


Originally Posted by: Brian Gaze 


 


Listening to NS in Scotland, I get the same impression.


Heavy Weather 2013
23 March 2020 14:24:45


As a matter of interest, how quickly are test results coming through? By that I mean, if I have a Covid-19 test today, how long will it be before I get the results or the result is fed into national statistics? Apparently, it's taking up to 7 days to get results back in Ireland. If that's common in other countries too, it means that there is a real lag before trends can be ascertained.


Originally Posted by: Lionel Hutz 


Apparently the time is 4-5 days which means you assumption is quite correct. This means we cannot compare positives on a day to the number of tests. Its a right old mess.


I really don't trust our figures at all. The only figure you can trust sadly is the number of fatalitys.


Mark
Beckton, E London
Less than 500m from the end of London City Airport runway.
Brian Gaze
23 March 2020 14:25:57


Trump signals change in coronavirus strategy that could clash with health experts






Trump tweeted late Sunday that the White House would ‘make a decision’ after 15-day period of social distancing ends


https://www.theguardian.com/world/2020/mar/23/trump-social-distancing-coronavirus-rules-guidelines-economy


 


PS: It looks as though the Tweets he made have now been deleted. Very difficult to know what the thinking is.




Brian Gaze
Berkhamsted
TWO Buzz - get the latest news and views 
"I'm not socialist, I know that. I don't believe in sharing my money." - Gary Numan
Gooner
23 March 2020 14:26:15


 


Apparently the time is 4-5 days which means you assumption is quite correct. This means we cannot compare positives on a day to the number of tests. Its a right old mess.


I really don't trust our figures at all. The only figure you can trust sadly is the number of fatalitys.


Originally Posted by: Heavy Weather 2013 


Is it ?


Remember anything after T120 is really Just For Fun



Marcus
Banbury
North Oxfordshire
378 feet A S L


Brian Gaze
23 March 2020 14:27:16


 


 


Listening to NS in Scotland, I get the same impression.


Originally Posted by: warrenb 

Suggested to me that today's death count will be similar or perhaps even lower than yesterday's. If it was significantly higher they wouldn't get away with "no change" for another 24 hours.


Brian Gaze
Berkhamsted
TWO Buzz - get the latest news and views 
"I'm not socialist, I know that. I don't believe in sharing my money." - Gary Numan
Maunder Minimum
23 March 2020 14:28:22


 


I heard a junior minister on LBC earlier this afternoon. The impression I got is there will be no changes announced today. 


Originally Posted by: Brian Gaze 


According to the Telegraph, all shops other than those considered "essential" will be told to close.


New world order coming.
Gooner
23 March 2020 14:29:18


Suggested to me that today's death count will be similar or perhaps even lower than yesterday's. If it was significantly higher they wouldn't get away with "no change" for another 24 hours.


Originally Posted by: Brian Gaze 


I know people are expecting an increase and an explosion in numbers , at the moment this really isn't happening is it ( which is good ) 


Remember anything after T120 is really Just For Fun



Marcus
Banbury
North Oxfordshire
378 feet A S L


xioni2
23 March 2020 14:29:43

The authorities in Lombardy have started publishing 'mobility' stats using mobile phone GPS data. 100% benchmark was on 20 Feb, then 34% on 15 March and 23% yesterday.

westv
23 March 2020 14:29:51


 


According to the Telegraph, all shops other than those considered "essential" will be told to close.


Originally Posted by: Maunder Minimum 


A lot of these seem to be closing anyway.


At least it will be mild!
Heavy Weather 2013
23 March 2020 14:30:48


 


According to the Telegraph, all shops other than those considered "essential" will be told to close.


Originally Posted by: Maunder Minimum 


Yes. Importantly I picked up that line as well. She specifically mentioned salons, building sits etc. 


 


Mark
Beckton, E London
Less than 500m from the end of London City Airport runway.
Retron
23 March 2020 14:38:51


Yes. Importantly I picked up that line as well. She specifically mentioned salons, building sits etc.


Originally Posted by: Heavy Weather 2013 


I'm going to look like a yeti by the time this is over - I really need a haircut, but can't get one as I'm in self-isolation.


I'm assuming petrol stations will be immune from closures too...


Leysdown, north Kent
Darren S
23 March 2020 14:43:59


I'm going to look like a yeti by the time this is over - I really need a haircut, but can't get one as I'm in self-isolation.


Originally Posted by: Retron 


Me too. I'm not in isolation for any reason other than I don't want to catch it! Having my hair cut by someone who may have caught the virus from another customer is too much of a risk IMO.



I'm assuming petrol stations will be immune from closures too...


Originally Posted by: Retron 


"Pay at pump" could stay available without having to interact with any staff member. However most of them sell groceries which seems like a more appealing option than supermarkets which take longer to get around.


Darren
Crowthorne, Berks (87m asl)
South Berks Winter Snow Depth Totals:
2023/24 0 cm; 2022/23 7 cm; 2021/22 1 cm; 2020/21 13 cm; 2019/20 0 cm; 2018/19 14 cm; 2017/18 23 cm; 2016/17 0 cm; 2015/16 0.5 cm; 2014/15 3.5 cm; 2013/14 0 cm; 2012/13 22 cm; 2011/12 7 cm; 2010/11 6 cm; 2009/10 51 cm
xioni2
23 March 2020 14:45:34


 I'm going to look like a yeti by the time this is over - I really need a haircut, but can't get one as I'm in self-isolation.


Originally Posted by: Retron 


I will soon need a haircut too, but I think I'll join you, come May there might be an army of Yetis 


I also had a 'smart' meter installation today. I didn't speak to them much and kept a large distance, but one of the guys asked to use the toilet. I told him to take a leak in the garden.


 

Chichesterweatherfan2
23 March 2020 14:48:42


 


I will soon need a haircut too, but I think I'll join you, come May there might be an army of Yetis 


I also had a 'smart' meter installation today. I didn't speak to them much and kept a large distance, but one of the guys asked to use the toilet. I told him to take a leak in the garden.


 


Originally Posted by: xioni2 


you,rotter, Xioni! 

Polar Low
23 March 2020 14:49:04

No 1 all over Darren the easy option it won’t matter as it’s always very hot in your place




 


I'm going to look like a yeti by the time this is over - I really need a haircut, but can't get one as I'm in self-isolation.


I'm assuming petrol stations will be immune from closures too...


Originally Posted by: Retron 

Bugglesgate
23 March 2020 14:56:23


 


Me too. I'm not in isolation for any reason other than I don't want to catch it! Having my hair cut by someone who may have caught the virus from another customer is too much of a risk IMO.


 


"Pay at pump" could stay available without having to interact with any staff member. However most of them sell groceries which seems like a more appealing option than supermarkets which take longer to get around.


Originally Posted by: Darren S 


Indeed !  Since it has become impossible to  get stuff delivered I have been using  village local shops - including  the local filling station with a Budgens attached.  I'll extremely pissed off if they close and I'm forced to  go into Newbury and traipse around a Superstore with hundreds of other people - Totally counterproductive


Chris (It,its)
Between Newbury and Basingstoke
"When they are giving you their all, some stagger and fall, after all it's not easy banging your heart against some mad buggers wall"
xioni2
23 March 2020 14:56:35

Greece stops all flights from/to the UK with immediate effect citing the lack of strict measures in the UK.

warrenb
23 March 2020 14:56:50
Yep, number 1 all over, saying that, on my head you can't really tell the difference, just looks like greyer skin.
Essan
23 March 2020 15:04:01


 


A lot of these seem to be closing anyway.


Originally Posted by: westv 



Aye, had a walk round town after I finished closing up my shop and about half seemed to be closed, including all charity and clothes shops - independents and chains alike.

Was feeling slightly guilty about shutting up before I was told too, but in the event I was behind many others!  



Andy
Evesham, Worcs, Albion - 35m asl
Weather & Earth Science News 

Anyone who is capable of getting themselves made President should on no account be allowed to do the job - DNA
Essan
23 March 2020 15:05:52


Me too. I'm not in isolation for any reason other than I don't want to catch it! Having my hair cut by someone who may have caught the virus from another customer is too much of a risk IMO.


Originally Posted by: Darren S 



I was going to get mine cut a couple of weeks ago ...... too late now.   Won't be the first time I've gone for the long haired hippy look though 

Edit: mind, if I get bored I may just shave it all off.  Not as though anyone is going to see it for a while!


Andy
Evesham, Worcs, Albion - 35m asl
Weather & Earth Science News 

Anyone who is capable of getting themselves made President should on no account be allowed to do the job - DNA
Jonesy
23 March 2020 15:11:22

I wonder how some of these Boots stores will act, the ones with a Pharmacy within the store, they'll have to keep the pharmacy open but surely not the rest of the store and with the same amount of staff.


They'd need a couple of days to remove all non essential stock I'd imagine to stop those using the pharmacy also picking up a Lipstick for Doris and Hair Dye for Mavis


 


Medway Towns (Kent)
The Weather will do what it wants, when it wants, no matter what data is thrown at it !
westv
23 March 2020 15:16:20


I wonder how some of these Boots stores will act, the ones with a Pharmacy within the store, they'll have to keep the pharmacy open but surely not the rest of the store and with the same amount of staff.


They'd need a couple of days to remove all non essential stock I'd imagine to stop those using the pharmacy also picking up a Lipstick for Doris and Hair Dye for Mavis


 


Originally Posted by: Jonesy 


Toiletries are pretty essential.


At least it will be mild!
Quantum
23 March 2020 15:16:35

Someone in my transmission chain is possibly getting tested today. Will be interesting to see if it comes back positive.


2023/2024 Snow days (approx 850hpa temp):
29/11 (-6), 30/11 (-6), 02/12 (-5), 03/12 (-5), 04/12 (-3), 16/01 (-3), 18/01 (-8), 08/02 (-5)

Total: 8 days with snow/sleet falling.

2022/2023 Snow days (approx 850hpa temp):

18/12 (-1), 06/03 (-6), 08/03 (-8), 09/03 (-6), 10/03 (-8), 11/03 (-5), 14/03 (-6)

Total: 7 days with snow/sleet falling.

2021/2022 Snow days (approx 850hpa temp):

26/11 (-5), 27/11 (-7), 28/11 (-6), 02/12 (-6), 06/01 (-5), 07/01 (-6), 06/02 (-5), 19/02 (-5), 24/02 (-7), 30/03 (-7), 31/03 (-8), 01/04 (-8)
Total: 12 days with snow/sleet falling.

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